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6. A clinical example of therapeutic inhibition of aldehyde dehydrogenase?
- ketoconazole
- disulphiram
- erythromycin
- grapefruit juice
7. Male specific CYPs in rats include:
- CYP2C6, CYP1A1
- CYP2C11, CYP3A2
- CYP2B1, CYP3B1
- CYP2C7, CYP2C19
8. Lack of bilirubin glucuronidation in neonates can lead to?
- hepatotoxicity
- kernicterus
- coumarin
- cyanosis
9. The AhR regulates which gene?
- CYP3A
- CYP4A
- CYP7A
- CYP1A
- CYP2B
10. CYP2D6 inhibited by?
- sulfaphenazole
- quinidine
- furafylline
- troleandomycin
11. What happens to the Km and Vmax in reversible competitive inhibition?
- Km and Vmax stay the same
- Km increases, Vmax increases
- Km increases, Vmax stays the same
- Km increases, Vmax decreases
12. Children show more rapid clearance of what drugs?
- warfarin and caffeine
- antipyrene and phenylbutazone
- acetaminophen and imeprmine
- theophylline and paracetamol
13. Male rats show intermittent levels of expression in?
- CYP2C7 and CYP2C11
- CYP2C11 and CYP2C22
- CYP2C7 and CYP2C22
- CYP2C7 and CYP2C12
14. Female rats show continuous high levels of expression in?
- CYP2C7 and CYP2C12
- CYP2C11 and CYP2C22
- CYP2C7 and CYP2C22
- CYP2C7 and CYP2C11
15. Glucocorticoids are known to induce?
- CYP2D6
- CYP2E1
- CYP3A family
- CYP2C11
16. No sex differences in CYPs in rats:
- CYP2C7, CYP2C19
- CYP2B1, CYP3B1
- CYP2C6, CYP1A1
- CYP2C11, CYP3A2
17. Phenobarbitone & bile acids can induce what gene(s)?
- CYP7A
- CYP1A
- CYP2B
- CYP4A
- CYP3A
18. Female dominant CYP in rats include:
- CYP2C7
- CYP2B1
- CYP2C19
- CYP2C11
19. CYP3A4 inhibited by?
- sulfaphenazole
- troleandomycin
- furafylline
- quinidine
20. Inflammation has what effect on CYP450 expression?
- responsive
- repressive
- inductive
- inclusive