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6. A clinical example of therapeutic inhibition of aldehyde dehydrogenase?

  • ketoconazole
  • disulphiram
  • erythromycin
  • grapefruit juice

7. Male specific CYPs in rats include:

  • CYP2C6, CYP1A1
  • CYP2C11, CYP3A2
  • CYP2B1, CYP3B1
  • CYP2C7, CYP2C19

8. Lack of bilirubin glucuronidation in neonates can lead to?

  • hepatotoxicity
  • kernicterus
  • coumarin
  • cyanosis

9. The AhR regulates which gene?

  • CYP3A
  • CYP4A
  • CYP7A
  • CYP1A
  • CYP2B

10. CYP2D6 inhibited by?

  • sulfaphenazole
  • quinidine
  • furafylline
  • troleandomycin

11. What happens to the Km and Vmax in reversible competitive inhibition?

  • Km and Vmax stay the same
  • Km increases, Vmax increases
  • Km increases, Vmax stays the same
  • Km increases, Vmax decreases

12. Children show more rapid clearance of what drugs?

  • warfarin and caffeine
  • antipyrene and phenylbutazone
  • acetaminophen and imeprmine
  • theophylline and paracetamol

13. Male rats show intermittent levels of expression in?

  • CYP2C7 and CYP2C11
  • CYP2C11 and CYP2C22
  • CYP2C7 and CYP2C22
  • CYP2C7 and CYP2C12

14. Female rats show continuous high levels of expression in?

  • CYP2C7 and CYP2C12
  • CYP2C11 and CYP2C22
  • CYP2C7 and CYP2C22
  • CYP2C7 and CYP2C11

15. Glucocorticoids are known to induce?

  • CYP2D6
  • CYP2E1
  • CYP3A family
  • CYP2C11

16. No sex differences in CYPs in rats:

  • CYP2C7, CYP2C19
  • CYP2B1, CYP3B1
  • CYP2C6, CYP1A1
  • CYP2C11, CYP3A2

17. Phenobarbitone & bile acids can induce what gene(s)?

  • CYP7A
  • CYP1A
  • CYP2B
  • CYP4A
  • CYP3A

18. Female dominant CYP in rats include:

  • CYP2C7
  • CYP2B1
  • CYP2C19
  • CYP2C11

19. CYP3A4 inhibited by?

  • sulfaphenazole
  • troleandomycin
  • furafylline
  • quinidine

20. Inflammation has what effect on CYP450 expression?

  • responsive
  • repressive
  • inductive
  • inclusive