CMP 7 - Introduction to cancer 0.0 / 5 ? BiologyCMPUniversityNone Created by: OwenBeesleyCreated on: 04-03-18 16:42 How many proteins could the typical adult cell potential encode? 30,000-50,000 1 of 19 What is neoplasia: A pathologic process in which a permanent alteration in a cell's growth controlling mechanism permits its continuous proliferation 2 of 19 What is neoplasm: A mass of tissue that is actively and progressively growing because of permanent defects in its cell's growth-controlling mechanisms 3 of 19 What is benign: 'GOOD', group of neoplasms that do not threaten life 4 of 19 What is malignant: 'BAD', group of neoplasms that invariably kill if not treated 5 of 19 What is cancer: Any malignant neoplasm 6 of 19 What is tumour: Any neoplasm 7 of 19 What is one gene that has to be mutated for colorectal cancer to occur: APC 8 of 19 What causes childhood cancers: Faults in cell differentiation, require less genetic events to occur 9 of 19 What is an example of childhood kidney cancer? Wilms' tumour 10 of 19 What causes Wilms' tumour? Failure of mesenchymal cell differentiation 11 of 19 What is a neuroblastoma? Disrupted differentiation of sympathetic cells 12 of 19 How can you do differentiation therapy? High dose-pulse retinoic acid 13 of 19 What affects quantitative levels of proteome? Altered gene expression - regulatory molecules, epigenetic alterations 14 of 19 What is an example of mutagenesis? Aflatoxin B1 binding to guanine 15 of 19 What is an example of an enzyme overexpressed in cancers? Telomerase 16 of 19 What is an example of fused genes? BCR + ABL (9;22), forms a fusion protein 17 of 19 What gene is amplified in neuroblastoma? N-MYC 18 of 19 What does EMT stand for? Epithelial-Mesenchymal Transition 19 of 19
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