Cells and Organelles-Detection of extracellular signals 2.0 / 5 based on 1 rating ? AllUniversityOther Created by: jessicaCreated on: 22-03-13 09:53 What are the factors affecting receptor binding? specificity, brief and reversible binding, affinity, location of binding, 1 of 11 What does the strength of the response depend on? concentration of messenger/ligand, number of receptors per target cell, receptor affinity for messenger 2 of 11 What is a receptor agonist? binds to receptor and mimics the normal response. 3 of 11 What is a receptor antagonist? binds to receptor and don’t produce a response, competes with normal ligand. 4 of 11 What is down regulation? receptor number decreases on target, results from excess messenger. sensitivity to messenger decreases and the tolerance develops 5 of 11 What are intracellular receptors? receptors for lipophilic messengers located in cytosol or the nucleus of target cells. 6 of 11 What are cell surface receptors? Receptors for lipophobic messengers that cannot permeate the plasma membrane 7 of 11 Name three other receptors ion-channel coupled receptors, g protein coupled receptors, enzyme coupled receptors 8 of 11 What are cytoplasmic receptors? activated by ligands they enter the nucleus through nuclear pores complexes. 9 of 11 What are nuclear receptors? nuclear receptor superfamily, -steroid hormone receptors, -non-steroid receptors, -orphan nuclear receptors. 10 of 11 What is the structure of the nuclear receptor? DNA-binding domains AF1 and AF2: transcription Activation Function 1 and 2 NLS : Nuclear localization sequence 11 of 11
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