Cell signalling

How do G-proteins work?
Signal at receptor males a subunit dissociate form b+y. GTP-GDP.this binds to adenyl cyclase and activates in turning ATP->cyclicAMP. cAMP binds to protein kinase A. R and enzyme separate. enzyme can then phosphorylate aa to create metabolic enzymes.
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What does G-proteins stand for?
Guanine nucleotide binding proteins.
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Receptor activation of phosphorylase C.
Adrenaline binds. GTP activated, which activated phosphorylase C. ionsitol phospholipid is phosphorylated. binds and opens Ca2+ channel.NT release in brain. activates PKC to phosphorylates proteins.
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What are G-protein coupled receptors.
e.g. B-adrenergic. outside loops bind to signals plasma membrane. with a G-protein interaction domain. Then second messengers.
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b-adrenergic
GS protein adenyl cyclase->cAMP
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A1-adrenergic
GQ protein. Phospholipase C -> IP3 and DAG.
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Card 2

Front

What does G-proteins stand for?

Back

Guanine nucleotide binding proteins.

Card 3

Front

Receptor activation of phosphorylase C.

Back

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Card 4

Front

What are G-protein coupled receptors.

Back

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Card 5

Front

b-adrenergic

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