Cell Cycle 0.0 / 5 ? BiologyCell CycleUniversityNone Created by: Ezz96Created on: 15-01-17 13:57 37298465110 Across 1. forms closed ring around the DNA to hold polymerase on DNA strand (7, 5, 4) 4. Cdk1 (mitosis) and cdk2 (6, 1) 6. Cells escape mitotic arrest (destruction of cyclin B even with SAC inhibiting APC) (8) 8. 6 hours. DNA synthesis - 2 sister chromatids for each chromosome (1, 5) 10. Polo-like-kinases (PLK), Aurora A, and Aurora B (4, 5, 7) Down 2. Organise the spindle where spindle divides and where microtubules organise (11) 3. MCM2-7 unwinds DNA (3, 8) 5. E3 Ubiuitin ligase - controls G1/S transition to remove cyciln components. Core subunits: RBX1 (ring finger) Cullin (Cul1) SKp1. Also has an E2 ubiquitin target protein. (3) 7. cdk2 (involved in G1/S ) (6, 1) 9. Both regulate spindle function and chromatid separation. Aurora A functions at centrosomes to maintain spindle integrity. Aurora B forms part of the chromosomal passenger complex (CPC) Aurora B also helps cyclin A package chromosomes (6, 1, 3, 6, 1)
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