Outline the process of Recognition in Phagocytosis and the role of PRRs and DAMPs.
1) Pattern recognition receptors (PRR) recognise pathogen assocoiated molecular patterns (PAMPs) which are essential to pathogen survival 2) Also recognise danger assosiated molecular patterns (DAMPs) produced by damaged cells
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Outline TLRs
Toll-Like Receptors, highly conserved, TLR subfamilies recognise diff PAMPs, expressed on many immune cells and some non-immune cells
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TLR1-TLR2-TLR6, recognise what type of PAMPs?
Lipids
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TLR7-TLR8-TLR9, recognise what type of PAMPs?
Nucleic Acids
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TLR4, recognise what type of PAMPs?
ligands from non-self
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Role of TLR in Pathogen Phagocytosis
1) TLR recognise particular PAMP 2) Inflammatory response, cytokines, chemokines and antimocrobial peptides 3) recruitment of neutrophils, macrophages
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What are the two main types of Phagocytes?
Neutrophils and Macrophages, Neutrophils ciculate in the blood, Macrophages migrate through the body
distributes lymph, transports lipids, macrophages reside in lymph nodes, dendritic cells migrate to lymph nodes after interacting with pathogen-adaptive
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Phagocytosis- Order The Following: Ingestion, Chemotaxis, Killing, Adherence and Digestion.
1) Mast Cell activated in damaged tissue and relase chemicals: Histamines and Cytokines 2) Histamines-blood vessels dilate, move out cause heat and redness 3) Walls more leaky blood plasma forced out, swelling and pain 4) Cytokines attract WBCs
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Front
Outline the process of Recognition in Phagocytosis and the role of PRRs and DAMPs.
Back
1) Pattern recognition receptors (PRR) recognise pathogen assocoiated molecular patterns (PAMPs) which are essential to pathogen survival 2) Also recognise danger assosiated molecular patterns (DAMPs) produced by damaged cells
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