Cardiac & Hypertensive Drugs 0.0 / 5 ? MedicineCardiac DrugsHypertension DrugsUniversityNone Created by: ..........Created on: 27-05-14 10:42 563124 Across 1. Inhibits vitamin k reduction enzyme preventing the carboxylation of clotting factors II, X, IX etc (8) 4. Inhibits the Na/K pump meaning Na concentrations in the cell increase. This decreases the concentration gradient for Na entering in the Ca/Na pump. This increases the force of contraction as there is thus more Ca in the myocyte (7) Down 2. Inhibits platelet thromboxane A2 synthesis which reduces aggregation (7) 3. Prevents vasoconstriction by antagonising the alpha -1 receptor preventing noradranline binding (5, 8) 5. Competitive antagonist at ß1 receptors and thus slows down the heart rate as noradrenaline cannot bind (1, 8, 10) 6. Metabolised to NO which causes vasodilation by increasing cGMP levels inside the cell which activates protein kinase G. This mainly acts on veins and thus reduces preload. (8, 10)
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