cancer gene mutations 2 0.0 / 5 ? PharmacyPH1122UniversityNone Created by: EmmanuelakyeCreated on: 03-02-20 13:33 mutagen is an agent causing genetic mutation 1 of 19 somatic mutations are acquired through spontaneous mutations(dna errors) and induced mutations(from attempt to repair dna damage) 2 of 19 what processes allow genomes to be copied properly high fidelity DNA synthesis,DNA proof reading, mismatch repair 3 of 19 how is dna replication carried out by dna polymerases with proofreading 4 of 19 how does dna proofreading work by removing incorrectly incorporated nucleotides 5 of 19 what does mismatch repair work corrects errors missed by proofreading after DNA synthesis 6 of 19 how are mismatches recognised as a distortion of dna geometry 7 of 19 how does mismatch repair work proteins cut out newly synthesised strands to be repaired 8 of 19 how do induced mutations arise cell’s attempt to repair DNA damage 9 of 19 what are intrinsic dna damage factors Oxidative and Hydrolytic damage 10 of 19 what are extrinsic dna damage factors Radiation, viruses 11 of 19 how do xrays cause damage double strand breaks 12 of 19 how do uv rays damage induces the formation of pyrimidine dimers 13 of 19 what are some examples of dna reacting chemicals deaminating agents, PAH, alkaloid, benzene 14 of 19 what is alkylation addition of methyl or ethyl groups on the DNA bases 15 of 19 what is adduct formation carcinogens reacting with dna bases, resulting in addition of bulky chemical groups 16 of 19 what are responses to dna damage cell cycle arrest, apoptosis, dna repair 17 of 19 what is translesion synthesis synthesis past the site of damage 18 of 19 apart from being mutagens, what else do carcinogens do act as tumour promoters by stimulating cell division 19 of 19
Comments
No comments have yet been made