Addison's disease

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What is the an alternative name for Addison's disease?
Hypoadrenalism
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What is Addison's disease?
Impairment of adrenal cortex due to loss of adrenal hormones
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What are the 3 adrenal hormones?
Glucocorticoids, mineralocorticoids, androgens
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How many people are affected by Addison's disease in the UK?
1 in 15,000 people.
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Which patient is most at risk of Addison's disease?
Females between ages 30-50 years.
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At what stage does onset of disease occur?
After 90% of the adrenal cortex in destroyed
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Which 2 hormones are responsible for most of the symptoms of the disease?
Cortisol and aldosterone
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What may be the common cause in MEDCs?
Auto-immune disease of renal cells
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What may be the likely cause in LEDCs?
Infection of adrenal glands due to poor sanitation
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What are some alternative reasons for Addison's disease?
Malignant tumour in adrenal glands, combination of infections, trauma, medication, vascular disturbances or metabolic effects
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Name some common symptoms of Addison's disease
Skin pigmentation, weight loss, fatigue, hypotension, loss of axillary hair, confusion, muscle weakness, cardiac atrophy, tachycardia
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What is the reason for increased skin pigmentation during Addison's disease?
Because MSH is a cleaved product of the polypeptide POMC when ACTH is cleaved
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What is the treatment?
Cortisone, DHEA and fludrocortisone hormone therapy + increase sodium ion intake during dehydration
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What is prednisone?
Prodrug of cortisol to replace cortisol
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What does Ovomax do?
Replace levels of DHEA androgens.
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Describe Addison's crisis
When a patient abruptly withdraws from hormone replacement therapy leading to hypoglycaemia, hyperkalaemia and hypotension
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What is the treatment for Addison's crisis?
Intravenous saline solution, dextrose (sugar), fludrocortisone and hydrocortisone
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Card 2

Front

What is Addison's disease?

Back

Impairment of adrenal cortex due to loss of adrenal hormones

Card 3

Front

What are the 3 adrenal hormones?

Back

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Card 4

Front

How many people are affected by Addison's disease in the UK?

Back

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Card 5

Front

Which patient is most at risk of Addison's disease?

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