multiplication (fibro, keratino, endothe). Fibroblast = temp matrix (eventually replace by collagen and elastin) granulation 4 days. epidermis restored prolif and migra keratinocytes. fibro = wound contraction
6 of 10
Proliferation and angiogenesis
dense network of capillaries (1st few days). deliver inflam cells, O2, nutrients. intiated = invasion of endothelial cells. endothelial cells undergo apoptosis and blood vessel density decreases as new tissue formed
7 of 10
re-epithelialisation
prolif and migra kearatinocytes. 18 hours post wounding. they break cell to cell contact "leap frog" migrate over. cease once wound closed
8 of 10
Wound contraction
Dermal fibroblasts into wound bed. contractile phenotype = myofibroblast (7-14 days). produce contractile protein alph smooth muscle actin = alignes across wound bed and contract wound brought together
9 of 10
Tissue remodelling
collagen deposited by fibroblasts. matrix continuously turned over by collagenase. collagen fibres become cross linked and form layer bundles. resemble unwounded skin structure. mature colagenous scar 1-2 years. 80% original strength
10 of 10
Other cards in this set
Card 2
Front
eliminate microorgansism. removal of debris and dead cell, healing signals (growth factors, cytokine)
Back
Inflammatory response
Card 3
Front
inflam cells squeeze through blood vessel wall
Back
Card 4
Front
arrive in minutes. phagacytosis. generate ROS (respiratory burst) secrete lysosomal enzymes = bacterial destruction. Proteases = break down damaged tissue. peak in 3 days. extruded in scab/phagacytosed/ lymph system
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