Blood Transfusion

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  • Created by: Emma Gill
  • Created on: 12-05-13 15:39

Blood Transfusion


Altermative should always be considered (stopping anti-coagulants, peri-operative blood salvage, Fe)

Blood Bank databases to match donor and recipient (ABO, Rh, HLA matching)

EU Legislations in terms of storage (temperature and number of days)

Screening for infectious diseases (Viruses and Bacteria mainly)

Report serious incidents to SHOT national surveillance system

Normally it is preferred to get blood products from returning donors or men (no anti-HLA antibodies)

Strict transfusion policies in UK (bedside checks to reduce human error)

Leukoreduction is done to remove T-lymphocytes which can cause GVHD due to donor being homozygous and recipient heterozygous for HLA haplotype.

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Blood Transfusion

Frozen Plasma (DIC, Haemorrhage, Liver disease, post warfarin)  - Acute lung associated injury

Platelets (Cardio-pulmonary bypass circuit induced damage, thrombocytopenia, defective platelets)

  • Sepsis, platelet refractoriness, viral infection, GVHD

Coagulation factor concentrated (replenish specific coagulation factors 8, 9, 12)

Albumin (replenish plasma volume, replace plasma proteins in burns patients)

Cryoprecipitate (replacement of fibrinogen and old haemophilia treatment)

Red Cells (anaemia) - Ciculatory overload, Fe overload, Haemolytic reaction (fever, acute renal failure, DIC), Sepsis, Parasitic infection, Viral infection

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