Mucas accumulates in the lungs, bacteria trapped in te mucas increase the possibility of infection
Mucas can block bronchioles, which reduces the number of alveoli in contact with fresh air so reduces the surface area for gas exchange.
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Digestion
Mucas blocks the pancreatic duct, so digestive enzymes can't reach the duodenum (small intestine) and food is not properly digested. This leads to tiredness and difficulty gaining weight.
Enzymes trapped within the pancreas cause fibrosed cysts and damage to insluin producing cells, leading to diabetes.
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Reproduction
In women, mucas can block the cervix preventing entry of sperm
In men, the vas deferns (sperm duct) is either missing or blocked with mucas, so sperm cannot leave the testes.
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Sweat
Sweat contains water and salts and the sweat of a person with CF contains more sodium and chloride than usual
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