IL-13
IL-13 produced by T cells (Th2). Shares many biological activities with IL-4.
IL-13 KO mice on a resistant background are susceptible to infection -> delayed Th2 response.
Goblet cell hyperplasia - increased resistance like molecule beta - impairs chemosensory function
increased gut permeabilit
increased epithelial cell turnover
increased muscle contraction
IL-14
C57B1/6 WT -> IL-4, -9, -13 -> T muris expulsion
C57B1/6 IL-4 KO -> IFN- gamma -> No expulsion.
Both IL-4 and IL-13 play important roles in resistance.
TNF-alpha
female BALB/c mice with IL-4 KO and anti-TNF also susceptible. Anti-TNF given to resistant mouse delays worm expulsion.
TNF-alpha may function through regulation of IL-4 and -13.
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