Induced fit theory
It has been found that the active site is often flexible. When the substrate enters the active site, the enzyme molecule changes shape slightly, fitting more closely around the substrate. Its like when a person puts on a wetsuit; the wetsuit shape changes to fit the body but returns to its original shape when taken off. This is known as the induced fit theory of enzyme action. Only a specific substrate will induce the change in shape of an enzyme's active site.
Activation energy
To convert substrates into products, bonds must change within and between molecules. Breaking chemical bonds require energy whilst energy is released when bonds form. The energy needed to break bonds and start the reaction is known as the activation energy. Without an enzyme, heating a substrate would provide this energy. The heat energy agitates atoms within the molecules, the molecules become unstable and the reaction can then proceed. In cells, enzymes reduce the amount of energy needed to bring about a reaction; this allows reactions to occur without raising the temperature of the cell.
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