Biology Unit 1

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  • Created by: Lucy
  • Created on: 05-01-13 15:37

Why can't CF lungs regulate the water content

  • In a person who has CF, the CFTR protein may be missing or not function.
  • If there is too little water in the mucus, Cl- cannot be secreted across the apical membrane and there is no blockage of the epithelial sodium ion channels.
  • Since the Na+ channels are always open, there is continual Na+ absorption by the epithelial cells.
  • The raised levels of Na+ draw chloride ions and water out of the mucus into the cells
  • This makes the mucus more viscous
  • Which makes it harder for the beating cilia to move it.
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