Atherosclerosis

1. Platelets stick to damanged wall of blood vessel. 

• Thromboplastin is released from damanged tissue and form platelets.
• Ca and vitamin K in plasma. 

2. Platelets stick to damanged wall and to each other, forming a platelet plug. 

3. Fibrin mesh traps blood cells, forming a clot. 

Prothrombin = Thrombin = soluble fibrinogen = insoluble fibrin. 

• Diet- hbc
• Inactivity- nbc
• High blood pressure
• Vasoconstriction- high blood pressure 

12. Platelets in contact with damanged artery wall. 

13. Cascade of chemical changes

14. Platelets become sticky 

15. Platelet plug forms 

16. Prothrombin

17. Thrombin

18. Fibrinogen 

19. Fibrin 

20. Tangled mesh 

21. Blood cells trapped 

22. A blood clot forms and the artery narrows

1. Rising blood pressure

2. Artery wall damanged 

3. Cholesterol accumulates

4. thromboplastin released from platelets/damanged tissue

5. Inflammatory response

6. Large white blood cells enter artery wall

7. Atheroma forms

8. Calcium salts and fibrous tissue accumulate 

9. Hard plaque forms 

10. Wall elasticity reduced

11. Atherosclerosis

12. Platelets in contact with damanged artery wall. 

13. Cascade of chemical changes

14. Platelets become sticky 

15. Platelet plug forms 

16. Prothrombin

17. Thrombin

18. Fibrinogen 

19. Fibrin 

20. Tangled mesh 

21. Blood cells trapped 

22. A blood clot forms

23. Artery narrows

• Endothelium gets damanged due to high blood pressure. 
• Endothelium breakages causes an inflammatory response- build up of white blood cells.
• White blood cells leave the blood vessel and enter the artery wall.
• White blood cells acccumulate chemicals from the blood, particually cholesterol, causing a build up of a deposit called an atheroma.
• Calcium salts and fibrous tissue build up causing hard swelling.

• Arteries become narrow,due to a gradual build up of fatty acids in their walls. 
• This fatty acid is called an atheroma.
• Atheromas lead to a narrowing of the Artery which can lead to not enough oxygen getting to the muscle.
• Which means the muscle can die.

• Arteriosclerosis means the hardening or loss of elasticity of medium or large arteries. 
• Atherosclerosis is a hardening of an artery specifically due to diet and lack of metabolism of fats.

• Coronary arteries supply blood to the heart muscle
• The right coronary artery supplies both the left and the right heart; the left coronary artery supplies the left heart.