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Corresondence between "normal" emotions and affective disorders. Relationship between minor events and depressed/anxious mood are analogous to those between severe events and depression/anxiety disorder, but in the disorders the affect lasts longer and is more disabling. Sadness and depression appear to activate similar distinctive brain regions (Mayberg et al., 1999). 

o  May be an attentional problem e.g. noticing information consistent with fear

o  May be an appraisal/attribution bias e.g. making stable, internal, global attributions for negative events (e.g. Alloy et al., 2000)

o  May be due to prolonged negative interpersonal interactions (Hammen, 1999)