Other slides in this set

Slide 2

Preview of page 2

Here's a taster:

The Blood Clotting Cascade!
Prothrombin (A soluble protein)
Thromboplastin (a protein) Fibrogen ( a soluble
is released. protein) is catalysed.
Thrombin is produced (an
enzyme)
Fibrin (insoluble fibres)
are produced.…read more

Slide 3

Preview of page 3

Here's a taster:

A step by step guide of the blood
clotting cascade:
· The protein thromboplastin is released from the
damaged blood vessel.
· Thromboplastin triggers the conversion of the
soluble protein prothrombin into the enzyme
thrombin.
· The thrombin then catalyses the conversion of
soluble protein fibrinogen into the insoluble fibre
fibrin.
· The fibrin fibres then tangle and form a mesh,
which sticky platelets and red blood cells get
trapped, forming a blood clot.…read more

Slide 4

Preview of page 4

Here's a taster:

around
blood cells
the body.
move into the
· This tends
arterial wall
to result in
and
high blood
accumulate
pressure.
chemicals
·from
Thisthe is
blood,
what such is as
3.
cholesterol.
called a
· A positive
·fatty
The
feedback
deposit has
looplining
started , as
to
build of
plaquesup,
raise
calledthe an 2.
blood
atheroma.
endo
pressure,
Calcium salts
and
and theliu
raised
fibrous
blood
tissuemalso in
pressure
build theup at
means
the site,
arter it is
resulting
more in 1.
likely
the y isthat
a plaque
dama
development
ofwill form.
hard
a ged,
swelling
causi
called plaque.
ng
· This causes
and
the arterial
Atheroma!
to lose
wallinfla
its elasticity.
mma…read more

Slide 5

Preview of page 5

Slide 6

Preview of page 6

Here's a taster:

How does atheroma formations link to
the blood clotting cascade?
· Atheromas can burst through the endothelium of
an artery, damaging the artery wall.
· This triggers the release of thromboplastin,
triggering the blood clotting cascade.
· This can lead to the complete blockage of the
artery, or could become dislodged and block a
blood vessel further along.
· The blood flow to tissue is then compromised and
can cause damage.
· It can also cause a heart attack (myocardial
infarction), stroke, and deep vein thrombosis.…read more

Slide 7

Preview of page 7
Preview of page 7

Slide 8

Preview of page 8
Preview of page 8

Slide 9

Preview of page 9
Preview of page 9

Slide 10

Preview of page 10
Preview of page 10

Comments

No comments have yet been made

Similar Biology resources:

See all Biology resources »See all resources »