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Slide 1

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Enzyme Inhibition
2.8…read more

Slide 2

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What is inhibition?
· Enzyme inhibition is when inhibitors that attach
themselves to enzymes in order to interfere indirectly
or directly interfere with the functioning of the active
site of an enzyme thus reducing the activity of the
· There are cases where by the inhibitor is bound so
strong that they can restrict the activity of the enzyme
causing it to become inactive permanently.
· Most inhibitors are temporary attachments, these are
called reversible inhibitors. There are two types
-Non-competitive…read more

Slide 3

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· This binds to the active site of the enzyme
· Its shape is similar to the substrate, thus allowing
it to fit into the active site
· These inhibitors `compete' with the substrate for
the available active site
· The difference between the concentration of
inhibitors and substrate that determines which
will gain the position in the active site, this
effecting enzyme activity (to work or not to work)…read more

Slide 4

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· Its purely up to the concentration on what will
occupy the active site after the inhibitor leaves it
as they're not permanent attachments
· The substrate would eventually bind to the active
site but depending on the concentration of the
competitive inhibitor if there is many of them the
longer it would take for there to be a an enzyme-
substrate complex.…read more

Slide 5

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Competitive - Examples
· Competitive inhibitors occur with an
important respiratory enzyme that acts on
succinic acid
· Another compound called malonic acid, can
inhibit the enzyme as its shape is very similar
to succinic acid
· Therefore it combines with the enzyme easily
and blocks succinic acid from the active site of
the enzyme.…read more

Slide 6

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Non - competitive
· These attach themselves any part of the enzyme
accept the active site
· This still alters the shape of the active site,
resulting in substrates unable to fit into the site,
therefore meaning the enzyme cannot function
· As the non-competitive inhibitor isn't competing
with anything, there is an increase in substrate
concentration, but this doesn't effect the
inhibition.…read more

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