Biological explanations for schizophrenia: genetic explaination

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Psychology unit 4 revision (schizophrenia)
Biological explanations for schizophrenia
Suggests that 1 or more of our genes we inherit from our parents can put us at
risk of schizophrenia.
Gottesman
AO1
Investigated the concordance rates between a schizophrenic individual and
their family of having schizophrenia.
Found that monozygotic twins who have identical genes only had a 48%
concordance rate of developing schizophrenia.
Whilst this shows schizophrenia could be genetic it also shows it also shows
other factors influence concordance rates, as if genes were a single factor
the concordance rates would be 100%
Also found that 1st degree relatives of the schizophrenic share 50% of their
genes but have different concordance rates which further suggests that
other factors such as nurture affect the chances of developing
schizophrenia.
AO2
Unreliable as the study doesn't separate nature from nurture- the chances
of a person developing schizophrenia may also be due to the way a person
was brought up. Therefore we can't be sure that all of the 48%
concordance rates are due to the MZ twins identical genes
Twin studies
AO1
Investigated concordance rates for schizophrenia between MZ and DZ
twins
Found that MZ twins had higher concordance rates than DZ twins. MZ
twins had a concordance rate of 39% whereas DZ twins had concordance
rates of only 5%
This shows that genes play a big role in explaining schizophrenia as DZ
twins have lower concordance rates than MZ twins because DZ twins only
share 50% of their genes, unlike MZ twins who share 100%
This suggests that MZ twins have higher chances of schizophrenia if there
twin is schizophrenic.
AO2

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Psychology unit 4 revision (schizophrenia)
Conflicting evidence- genetic influence of MZ twins varies between studies.
Gottesman showed concordance rates of 48% whereas this study shows them
as 39%. Therefore results are not reliable due to the differences so we
can't be sure genes affect the chances of schizophrenia.
Kety et al
AO1
Studied siblings who were separated then adopted.…read more

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Psychology unit 4 revision (schizophrenia)
Only looked at the genetic link between children and mothers, not fathers.
Therefore we can't be sure of the father's genetic influence on the chances
of the child getting schizophrenia.
Genetic breeding of mice
AO1
Breeding mice to be schizophrenic by turning off the gene that regulates
calcineurin
Mice showed symptoms of schizophrenia such as social withdrawal
Suggest the PPP3CC gene could cause some symptoms of schizophrenia.…read more

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