Topic 8

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  • Topic 8
    • Genetic Variation
      • Random Genes
        • Random Assortment: of parental chromosomes
        • Crossing over: Swapping of DNA between chromosomes
        • Random Fertilization: between sperm and egg
      • Keywords
        • Genotype: the genes
          • Phenotype: the physical characteristicof the organism
            • Homozygous: both alleles the same
              • Heterozygous: 2 alleles for the gene are different
                • Dominance: phenotype expressed all the time
                  • Recessive: only expressed when 2 alleles are the same
                    • Codominant: where both aleles influence the phenotype
                      • Multiple alleles: when there are 2 alleles which code for a trait ABO blood
    • Genetic Diagrams
      • Genetic Crosses
      • Pedigree Diagrams
    • Di-hybrid Inheritance
      • 2 non-linked genes are inherited indendently of each other
    • Autosomal Linkage
      • Any chromosome not involved in the inheritance of sex found on the same chromosome
    • Sex Linkage
      • Males XY, females **, males more likely to have genetic diseases
    • Chi Squared
      • expected vs observed
    • Selection Pressure
      • Directional: moves the value of a characteristic in one direction changes the whole population
      • Stabilising: Acts against change by making favourable characteristic more common in an unchanging environment
      • Disruptive: leads to a change making the extreme values of a characteristic more common
    • Genetic Drift
      • Change of alleles due to chance not selection; due to random sexual reproduction; accidents preventing reproduction; alleles not passed on; effects greater in small populations; not not directional
    • Population
      • Founder effect
        • a new population is established by a few individuals so the frequency of alleles is different
      • Population Bottleneck
        • only a small number of individuals survive a major event, the frequency of alleles is different within the surviving population
    • Hardy Weinberg Equation
      • Allele frequency's should be constant through generations as long as: -there is no mutations -random mating -a large population - no migration -no selection pressures

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