Muscle contraction cycle
- Created by: JS007
- Created on: 15-12-17 13:28
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- The Muscle contraction cycle
- Stage 1: Relaxed - Lack of Ca2+; tropomyosin blocks binding site on actin, myosin head is cocked but detached.
- Stage 2: Ca2+ influx - Ca2+ binds to troponin, causing a conformation change
- Stage 3: Tropomyosin moves - Tropomyosin moves out the way of the actin binding site, allowing the myosin head to bind
- Stage 4: ATP binds to the myosin head- This allows the myosin head to detach
- Stage 5: ATP is hydrolysed into ADP and Pi- This results in the myosin head becoming 'cocked'
- Stage 6: Myosin head binds - This time further along the actin filament, forming a weak cross-bridge
- Stage 7: Pi is lost- Allows myosin head to form a strong cross-bridge & causes a conformation change resulting in the 'power stroke'
- Stage 8: ADP is lost- The myosin head detaches and the cycle returns to rest
- Stage 1: Relaxed - Lack of Ca2+; tropomyosin blocks binding site on actin, myosin head is cocked but detached.
- Stage 2: Ca2+ influx - Ca2+ binds to troponin, causing a conformation change
- Stage 3: Tropomyosin moves - Tropomyosin moves out the way of the actin binding site, allowing the myosin head to bind
- Stage 4: ATP binds to the myosin head- This allows the myosin head to detach
- Stage 5: ATP is hydrolysed into ADP and Pi- This results in the myosin head becoming 'cocked'
- Stage 6: Myosin head binds - This time further along the actin filament, forming a weak cross-bridge
- Stage 7: Pi is lost- Allows myosin head to form a strong cross-bridge & causes a conformation change resulting in the 'power stroke'
- Stage 8: ADP is lost- The myosin head detaches and the cycle returns to rest
- Stage 8: ADP is lost- The myosin head detaches and the cycle returns to rest
- Stage 7: Pi is lost- Allows myosin head to form a strong cross-bridge & causes a conformation change resulting in the 'power stroke'
- Stage 6: Myosin head binds - This time further along the actin filament, forming a weak cross-bridge
- Stage 5: ATP is hydrolysed into ADP and Pi- This results in the myosin head becoming 'cocked'
- Stage 4: ATP binds to the myosin head- This allows the myosin head to detach
- Stage 3: Tropomyosin moves - Tropomyosin moves out the way of the actin binding site, allowing the myosin head to bind
- Stage 2: Ca2+ influx - Ca2+ binds to troponin, causing a conformation change
- Stage 1: Relaxed - Lack of Ca2+; tropomyosin blocks binding site on actin, myosin head is cocked but detached.
- Stage 8: ADP is lost- The myosin head detaches and the cycle returns to rest
- Stage 7: Pi is lost- Allows myosin head to form a strong cross-bridge & causes a conformation change resulting in the 'power stroke'
- Stage 6: Myosin head binds - This time further along the actin filament, forming a weak cross-bridge
- Stage 5: ATP is hydrolysed into ADP and Pi- This results in the myosin head becoming 'cocked'
- Stage 4: ATP binds to the myosin head- This allows the myosin head to detach
- Stage 3: Tropomyosin moves - Tropomyosin moves out the way of the actin binding site, allowing the myosin head to bind
- Stage 2: Ca2+ influx - Ca2+ binds to troponin, causing a conformation change
- Stage 1: Relaxed - Lack of Ca2+; tropomyosin blocks binding site on actin, myosin head is cocked but detached.
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