sleep - endogenous pacemakers, exogenous zeitgebers
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?- Created by: mollskie49
- Created on: 06-06-13 16:29
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- Sleep
- endogenous pacemakers
- suprachiasmatic nucleus (SCN)
- Tiny clusters of nerve cells - in hypothalamus
- above optic chiasm (optic nerve cross over)
- info about light - from eyes - via optic nerve
- automatic shifts
- pair of structures - one hemisphere - ventral and dorsal
- ventral quickly reset by external clues
- dorsal less effective - more resistant to being reset
- ventral quickly reset by external clues
- pair of structures - one hemisphere - ventral and dorsal
- automatic shifts
- info about light - from eyes - via optic nerve
- above optic chiasm (optic nerve cross over)
- Tiny clusters of nerve cells - in hypothalamus
- the penal gland and melatonin
- SCN siginals to the pineal gland to increase malatonin at night
- induces sleep - inhibits brain mechanism
- lizards - third eye - top of skull - receives light info
- induces sleep - inhibits brain mechanism
- SCN siginals to the pineal gland to increase malatonin at night
- SCN demonstrated in animal studies
- mutant rats - 20hrs
- transplanted SCN into hamsters - had mutant rats rhythm
- mutant rats - 20hrs
- body's separate oscillators can desyncronise from SCN
- kate aldcroft - cave
- temp 24hr rhythm
- sleep 30hr cycle
- desynchronized rhythm similar to jet lag
- sleep 30hr cycle
- temp 24hr rhythm
- kate aldcroft - cave
- suprachiasmatic nucleus (SCN)
- exogenous zeitgebers
- entrainment
- resseting biological clock
- opposite to free running
- resseting biological clock
- light
- dominant zeitgebers
- can reset SCN and other oscillators in the body
- protein CRY is light sensitive
- can reset SCN and other oscillators in the body
- dominant zeitgebers
- shin light on back of knee
- circadian rhythm shifted
- artifician lighting does have an effect
- circadian rhythms can be entrained by artificial light
- exposure to artificial lighting disrupts circadian rhythms and the production of melatonin
- women in industrialized societies more likely to develop breast cancer
- social clues
- biologists thought social clues were the main zeitgebers for circadian rhythms
- eat meals at socially determined times
- all parts of the body have own oscillating rhythms
- liver and heart likely to be reset from eating
- all parts of the body have own oscillating rhythms
- eat meals at socially determined times
- biologists thought social clues were the main zeitgebers for circadian rhythms
- temperature
- cold blooded animals
- clod temp time to rest
- warm temp time for activity
- changes in body temp - governed by circadian clock
- temp changes entrain other circadian rhythms
- changes in body temp - governed by circadian clock
- warm temp time for activity
- clod temp time to rest
- cold blooded animals
- entrainment
- the ticking of the biological clock
- mutilation in genes
- familial advanced sleep-phase syndromedefect in the PER genes
- morning, two proteins, clock and cycle (CLK-CYC) bind
- CLK - CYC produce period and time (PER -TIM)
- PER - TIM render CLK - CYC inactive
- therefore PER - TIM start to decrease (negative feedback)
- loop last 24hrs
- therefore PER - TIM start to decrease (negative feedback)
- PER - TIM render CLK - CYC inactive
- CLK - CYC produce period and time (PER -TIM)
- animal studies
- issues of harm to animals
- cant be generalized to humans
- important to check findings against human research
- cant be generalized to humans
- issues of harm to animals
- the blended system
- the running of the biological clock is combined endogenous - exogenous exercise
- mutilation in genes
- endogenous pacemakers
- the blended system
- the running of the biological clock is combined endogenous - exogenous exercise
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