Respiration of glucose, Unit 1 Module 4 (edexcel)

Gylcolysis, The link reaction, The krebs cycle and oxidative phosphorylation.

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  • Respiration of Glucose (4 stages)
    • Glycolysis
      • This happens in the cytoplasm of all cells. It doesn't need oxygen and can take  place in aerobic and anaerobic conditions.
      • A metabolic pathway where each glucose molecule is broken down to two molecules of pyruvate.
        • Stage1: Phosphorylation
        • Stage 2: splitting of hexose 1,6-bisphosphate.
        • Stage 3: Oxidation of triose phosphate.
        • Stage 4: Conversion of triose phosphate to pyruvate
    • The Link Reaction.
      • This happens in the matrix of the mitochondria.
        • It converts pyruvate to acetate.
      • 2pyruvate + 2NAD + 2CoA -> 3CO2 + 2reduced NAD+ 2acetyl CoA
    • The Krebs cycle
      • Takes place in the mitochondrial matrix.
      • Oxides acetate to make carbon dioxide.NAD and FAD are reduced. ATP is made by substrate-level phosphorylation.
    • Oxidative phosphorylation.
      • Is the formation of ATP by adding a phosphate group to ADP, in the presence of oxygen, which is the final acceptor.
      • How it happens
        • 1. As protons flow through an ATP synthase enzyme, they drive a rotation  of park of the enzyme and join ADP and P to for ATP.
        • 2. The electrons are passed from the last electron carrier ain the chain to molecular oxygen, which is the final acceptor.
        • 3. Hydrogen ions also join so that oxygen is reduced to water.


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