hypoglycaemia

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  • Hypoglycaemia
    • Definition
      • a biochemical symptom, low blood sugar
    • Symptoms
      • Lethargy, Tremors, Poor feeding, Irritable, Seizure, Coma
    • Causes
      • PHHI
      • Limited glycogen stores
        • Prematurity
        • intrauterine growth retardation
      • increased glucose use
        • hyperthermia
        • sepsis
        • GH deficiency
      • Decreased glycogen breakdown/ glucose generation/ use of alternative fuels
        • inborn errors of metabolism
          • Medium chain acyl-CoA dehydrogenase deficiency
          • glycogen storage diseases
          • maple syrup urine disease
        • adrenal insufficiency
          • Addison's Disease
          • ACTH deficiency
      • depleted glycogen stores/ starvation
      • Hyperinsulinism
        • Endogenous/ Exogenous
    • Treatment
      • Emergency- IV dextrose
      • others depend on cause
        • Causes
          • PHHI
          • Limited glycogen stores
            • Prematurity
            • intrauterine growth retardation
          • increased glucose use
            • hyperthermia
            • sepsis
            • GH deficiency
          • Decreased glycogen breakdown/ glucose generation/ use of alternative fuels
            • inborn errors of metabolism
              • Medium chain acyl-CoA dehydrogenase deficiency
              • glycogen storage diseases
              • maple syrup urine disease
            • adrenal insufficiency
              • Addison's Disease
              • ACTH deficiency
          • depleted glycogen stores/ starvation
          • Hyperinsulinism
            • Endogenous/ Exogenous
    • Hypoglycaemic screen
      • Glucose and lactate
        • fluoride oxalate tube
      • Insulin, C-peptide, cortisol, GH
        • plain tube on ice
      • Ammonia
        • heparinised tube on ice
      • ketones and free fatty acids
        • fluoride oxalate tube
      • amino acids, electrolytes
        • heparanised tube
      • blood drops
        • onto gluthrie test card
          • acyl-carnitine profile

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