Covid
- Created by: Emilyburkee
- Created on: 01-01-23 11:37
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- Coronaviruses
- epi
- 4 common strains
- 229E
- APN receptor
- OC43
- 9O-acyclated sialic acid
- HKU1
- 9O-acyclated sialic acid
- NL63
- HKU1
- 229E
- 3 more severe strains
- SARs
- haperanin sulphate/ ACE2
- NL63
- haperanin sulphate/ ACE2
- MERS
- DPP4/ sialic acid
- SARS-CoV-2
- ACE2
- SARs
- 4 common strains
- Virology
- envoloped
- +sense
- ssRNA
- large RNA genome
- Order = Nidovirales and family cornavirdea
- Genus alphacoronaviruses include: 229E, NL63Betacoronaviruses include: SARS1, MERS, SARS-CoV-2, OC43, HKU-1,
- budding takes place not at the plasma membrane
- Pandemic potentail
- eco destruction
- genetic diversity
- interspecies transmission
- Pathogenesis
- infect respiritory hair cells
- spikes bind and unravel inserting itself into the membrane allowing fusion
- sugars make spike proteins less detectable
- Knot in RNA = allows for less RNA reg proteins vs non structural
- ribosome starts translation of non structural proteins ( chain cut)
- viral RNA replicated + nucleocapsid proteins package it
- once spike preotins made, the nucloecapsid packaged RNA causes membrane to bud off
- membrane compartment fuses with membrane and virus relasesd
- causes inflammation and immune injury
- Untitled
- epi
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