Brunner et al

G543 Turning to crime 

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  • Created by: jade
  • Created on: 19-04-13 14:06
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  • Brunner et al - genetic abnormality
    • Five affected males from one family
  • Netherlands
    • Brunner et al - genetic abnormality
      • Five affected males from one family
  • borderline mental retardation and abnormal violent behaviour
    • Netherlands
    • Data Collected
      • analysis of urine samples
        • Data Collected
        • 24 Hours
          • Results
            • disturbed monoamine metabolism
              • Results
              • deficit of the enzyme monoamine oxidase A
                • Point Mutation identified in the X Chromosome
                  • In the gene responsible for MAOA production
                • Conclusion
                  • MAOA is involved in serotonin metabolism
                    • Conclusion
                    • Responsible for the mental retardation
                      • MAOA is involved in serotonin metabolism
                      • associated with recognizable behavioral phenotype
                        • Inability to regulate aggression
                          • associated with recognizable behavioral phenotype
                          • Not all family members with mental retardation were violent
                            • Responsible for the mental retardation
                            • Cannot be generalized
                              • Not all family members with mental retardation were violent
                              • Christiansen
                                • Monozygotic - (identical) 52% concordance with criminality
                                  • Christiansen
                                  • dizygotic - 22% concordance
                                    • Price et al XXY Chromosomes
                                      • Small sample size
                                        • Objective and reliable
                                          • analysis of urine samples
                                          • Only Looks at Biological - Reductionist
                                            • Could Provide  medication
                                              • Increased Internal and External Validity
                                                • Ethnocentric
                                                  • Unrepresentative
                                                    • Small sample size
                                                    • Concurrent Validity Increased
                                                      • Price et al XXY Chromosomes
                                                      • Both found Biological links with  crime
                                                        • Concurrent Validity Increased

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