biological explanations for schizophrenia - describe
- Created by: Abi Crew
- Created on: 13-05-22 12:40
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- biological explanations for schizophrenia
- dopamine hypothesis
- schizophrenia said to be caused by an excess of dopamine activity in the brain Snyder (1976)
- hyperactivity in D2 receptor = positive symptoms
- hypofunctionality in D1 receptor = negative symptoms
- theory proposed after observations of the effect of amphetamine, which enhances dopamine effects
- rognli and bramness (2015)
- amphetamine psychosis has similar symptoms to schizophrenia
- Brain imaging studies using injections of dopamine-related chemicals have suggested that there are differences in the dopamine behaviour of schiz + non schiz.
- L.Farde (1997)
- Horga et al (2016)
- Schizophrenia symptoms treated the same way as Parkinsons, which may be caused by dopamine abnormalities
- Correll and Schenck (2008)
- schizophrenia said to be caused by an excess of dopamine activity in the brain Snyder (1976)
- enlarged ventricles
- Too simplistic to think of schizophrenia as just dopamine related
- Proposed that abnormal dopamine levels could vary by brain region,
- Davis et al. (1991)
- frontal lobe - low levels of dopamine could explain negative symptoms
- Scans consistently show structural abnormalities in schizophrenics
- Differences seem to centre around ventricle size
- naturally occurring fluid cavities in the brain
- Weinberger et al (1980) found significant ventricular enlargement in those with schizophrenia
- Torrey (2002) ventricles in schizophrenics 15% larger
- Differences seem to centre around ventricle size
- HOWEVER - thought that is not the enlarged ventricles causing schizophrenia, but the loss of brain tissue that would have otherwise occupied that space
- dopamine hypothesis
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