Amino acid synthesis
- Created by: SamDavies
- Created on: 22-04-19 18:55
View mindmap
- Amino acid synthesis
- Strecker synthesis
- Reagents: aldehyde amine and HCN
- End product is racemic mixture
- Intermediate is alpha amino nitrile
- Reagents for hydrolysis of amino nitrile: H3O+, H2O and heat
- Using carboxylic acid derivatives
- Acyl chloride + amine ==> amide + HCl
- Cl is a good leaving group
- Carboxylic anhydride + secondary amine ==> amide + carboxylic acid
- Ester + secondary amine ==> amide + alcohol
- Reagents: acid or base + heat
- Acyl chloride + amine ==> amide + HCl
- Using carbodiimide agents, e.g. DCC
- Reagents: DCC, carboxylic acid, secondary amine
- Produces amide and stable urea product
- Amino acid hydrolysis
- Acidic hydrolysis
- Amino acid + H3O+ ==> Carboxylic acid + NH4+
- Also uses H2O and heat
- Basic hydrolysis
- Amino acid + OH- ==> carboxylate ion + NH3
- Basic hydrolysis
- Basic hydrolysis
- Amino acid + OH- ==> carboxylate ion + NH3
- Acidic hydrolysis
- Strecker synthesis
Comments
No comments have yet been made