1,2 Disconnection
- Created by: S
- Created on: 24-03-17 20:54
View mindmap
- 1,4-Functional disconnections
- 1,4 dicarbonyl
- Disconnection 2 - Acyl anion
- Cyanide - KCN /HCM DMSO 80C
- To convert to carbonyl add dil HCl and ROH
- Nitro- RNO2 NaOH
- To convert to carbonyl add TiCl3 ad H2O
- Cyanide - KCN /HCM DMSO 80C
- Disconnection 1 - Cationic synthon with a halide Br2,AcOH
- Disconnection 2 - Acyl anion
- 1,4-hydroxyl carbonyl
- If its a ketoester we can selectively reduce the ketone only using NaBH4 and MeOH
- Diketone
- Enolate opening of epoxide - I)NaOEt epoxide ii)HCl,H2O iii)-CO2
- Difunctionalistion of acetylenes I)alkyne with nBuli and RCHO x2 ii) H2 Pd/C
- 1,4 dicarbonyl
Comments
No comments have yet been made