week 3 drugs

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  • Created by: hadar
  • Created on: 11-02-16 17:34
Temozolomide (alkylating agent)- mechanism of action
alkylate N7 or methylate O6 on guanine/ inhibit transmethylation of methyl groups of methionine into t-RNA/ produce peroxides as metabolites
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Temozolomide (alkylating agent)- therapeutic affect
prevent cell cycle progression and inhibit DNA synthesis and cell division and cell growth through alkylation of the DNA and RNA/ tumour shrinkage, inhibit growth and inhibit matastasis
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Carmustine (alkylating agent)- mechanism of action
more selective for crosslinking N7 alkylation
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Carmustine (alkylating agent)- therapeutic affect
prevent cell cycle progression and inhibit DNA synthesis and cell division and cell growth through alkylation of the DNA and RNA/ tumour shrinkage, inhibit growth and inhibit matastasis
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Lomustine (alkylating agent)- mechanism of action
more selective for crosslinking and methylation of 06
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Lomustine (alkylating agent)- therapeutic affect
prevent cell cycle progression and inhibit DNA synthesis and cell division and cell growth through alkylation of the DNA and RNA/ tumour shrinkage, inhibit growth and inhibit matastasis
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Procarbazine (nonclassic alkylating agent)- mechanism of action
more selective for crosslinking and t-RNA and hydrogen peroxide
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Procarbazine (nonclassic alkylating agent)- therapeutic affect
prevent cell cycle progression and inhibit DNA synthesis and cell division and cell growth through alkylation of the DNA and RNA/ tumour shrinkage, inhibit growth and inhibit matastasis
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BCG therapy- mechanism of action
binding to finbronectin-->urothelial activation--> inflammatory response-->CD4+, Th1 response--> secretion of cytokines and cheekiness
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BCG therapy- therapeutic affect
→ antibodies kill the tumour cells either the compliment system or the activation of NK cells (antibody dependant cellular cytotoxcicity) Antibodies recruit NK cells to lyse them and producing cytotoxic granules.
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Card 2

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prevent cell cycle progression and inhibit DNA synthesis and cell division and cell growth through alkylation of the DNA and RNA/ tumour shrinkage, inhibit growth and inhibit matastasis

Back

Temozolomide (alkylating agent)- therapeutic affect

Card 3

Front

more selective for crosslinking N7 alkylation

Back

Preview of the back of card 3

Card 4

Front

prevent cell cycle progression and inhibit DNA synthesis and cell division and cell growth through alkylation of the DNA and RNA/ tumour shrinkage, inhibit growth and inhibit matastasis

Back

Preview of the back of card 4

Card 5

Front

more selective for crosslinking and methylation of 06

Back

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