Why type of mixing is non-spontaneous and its demixing is also non-spontaneous
Neutral mixing
1 of 29
What is the main mechanism of mixing in an agitator mixer, e.g. planetary and ribbon agitators?
Convection
2 of 29
What is the main mechanism of mixing in high shear mixer-granulators such as a tumbling agitator?
Shear force
3 of 29
What is the main mechanism of mixing in fluidised bed mixing?
Diffusion
4 of 29
This type of density includes deep intraparticular pores and it excludes large pores/void spaces so it is the most dense. Vp is measured by displacement of helium.
Particular density
5 of 29
This type of density includes interparticular pores and excludes deep intraparticular pores, so it has intermediary density. Vg measured by displacement of mercury
Granular density
6 of 29
This type of density includes void spaces, it relates to packing and is measured in a cylinder. It is the least dense.
Bulk density
7 of 29
Mixing index = content standard deviation random mix / content standard deviation sample. True or false?
True
8 of 29
Which particle size reduction method involves 3 blades rotating and shredding material before the particles can pass through a size-specific mesh underneath? Coarse but soft particles
Cutting mill
9 of 29
Which particle size reduction method involves two heavy rollers coming together to compress the material between them? Coarse but hard particles
Roller mill
10 of 29
Which particle size reduction method involves a blade cutting powder small enough to fall through holes? For coarse but hard particles.
Hammer mill
11 of 29
Which particle size reduction method involves dense steel balls in a vibrating mill which allow the powder to be grinded all at once? For fine particles.
Ball mill
12 of 29
Put the following stages of granulation ball growth in chronological order
Wet granulation can occur with granulation fluid +/- binder. True or false?
True
15 of 29
If a granule was formulated with a lot of fluid, will it be porous or dense after drying?
Porous
16 of 29
What is the typical amount of water used in granule formulation as a % of the weight of the dry powder mixture?
20-50%
17 of 29
What are the disadvantages of high shear granulation?
Potential for overgranulation
18 of 29
What are the two methods of dry granulation?
Roller compaction and slugging
19 of 29
Which dry granulation method involves the adherence to particles on a bed which are sprayed with fluid causing coalescence, before evaporating due to the warm air?
Which drying method involves a wet solid in contact with a hot surface?
Conduction
22 of 29
Which drying method involves drying at very low temperatures and is now rarely used?
Vacuum oven
23 of 29
Which drying method uses microwaves to dry the granules rapidly at low temperatures? Reduces solute migration, good for hazardous materials and small batch sizes.
Radiation
24 of 29
Which drying method involves drying individual liquid droplets into a solid particle. Used in DPIs and has efficient heat/mass transfer, rapid evaporation and improved flow
Spray drying
25 of 29
Which drying method involves water sublimation. It is used for heat sensitive material, and a light and porous solid is produced.
Freeze drying
26 of 29
What is the movement of solution to surface with any solid dissolved in it, causing the surface to be populated with the solid?
Solute migration
27 of 29
What is the movement of solute from granule to granule (so some granules are drug-free, others contain lots of drug)? Usually occurs during tray drying
Integranular migration
28 of 29
What is movement within a single granule? The solute moves to the surface of the granule
Intragranular migration
29 of 29
Other cards in this set
Card 2
Front
What is the main mechanism of mixing in an agitator mixer, e.g. planetary and ribbon agitators?
Back
Convection
Card 3
Front
What is the main mechanism of mixing in high shear mixer-granulators such as a tumbling agitator?
Back
Card 4
Front
What is the main mechanism of mixing in fluidised bed mixing?
Back
Card 5
Front
This type of density includes deep intraparticular pores and it excludes large pores/void spaces so it is the most dense. Vp is measured by displacement of helium.
Comments
No comments have yet been made