Unit 2 Quiz

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A 51 year-old woman with high-grade non-Hodgkin lymphoma affecting her paranasal sinuses is treated to prevent spread of the lymphoma to her brain. This involves injection into the cerebro-spinal fluid of a drug that inhibits dihydrofolate reductase and t
Methotrexate

Reasoning : Methotrexate is a Anti-metabolite,(Inhibiting nucleic acid base synthesis – by preventing folate production) It prevents Di
1 of 17
Simit fainted after donating blood to the transfusion service.
What describe the changes in the volume of his extracellular fluid (ECF) and intracellular fluid (ICF)?
**Decrease in ECF volume, Unchanged ICF volume**

Reasoning: As Samit was donating blood, blood was lost directly form the ECF volume, decreasing the ECF volume.
2 of 17
Minimum effective dose = 580mg
Median effective dose = 800mg
Minimum toxic dose = 1820mg
Median toxic dose = 2200mg
Median lethal dose = 3030mg

A 14 year old boy is being started on drug X. This drug has a very narrow therapeutic index window. The prope
**2.75**

Reasoning: The formula for therapeutic index is Median toxic dose/median effective dose. Using the data given in the question we get the calculation of 2200/800 which is 2.75. All other values are not needed.
3 of 17
Neutrophils are an integral part of the innate immune system. chemotaxis allows movement of neutrophils .
What biological process found in the neutrophil allows for the actual movement of the neutrophil?
amoeboid movement
4 of 17
What value below is used to compare the efficiency of dug?
EC 50
5 of 17
What is the base sequence for the start codon?
AUG
6 of 17
What vertebrae is the transpyloric plane?
L1
7 of 17
At what level the inferior mesenteric artery is found?
L3
8 of 17
Marcus, a 29 year old male, visits his phlebologist to find out his blood volume. He was injected with 5ml of 3mg/mL of Evan's blue. Half an hour later, a blood sample was taken where the plasma concentration of Evan's blue in Marcus' blood was 4 microgra
6.8L
9 of 17
What complex is needed to allows the cell to enter the M phase?
Cyclin B-CDK1
10 of 17
What facilitates the process of joining the okazaki fragments during DNA replication?
DNA ligase
11 of 17
Fareeha, was at her OSCE's, where she was asked to look into the microscopes with a sample of a jejunum.

What is the name of the most outer layer of the jejunum?
Serosa
12 of 17
In anaphase, cohesion between the sister chromatins are broken.
What causes the breakage of cohesion between the sister chromatids?
Cyclin B - CDK 1
13 of 17
Spliceosomes are used in the process of RNA splicing. There are 2 composed to the Spliceosomes, with one being small nuclear RNAs (snRNAs)
Other than small nuclear RNAs, what is another component of the spliceosome?
Small ribonucleoprotein (snRNPs)
14 of 17
A 64-year-old male comes to the GP complaining of weight loss. He also reveals a loss of appetite and blood in his stools. Examination reveals a mass in his abdomen and is immediately referred to an oncologist on the two-week referral pathway. He undergoe
APC
15 of 17
A 60-year-old man presents to the clinic with breathlessness. An urgent chest X-ray is arranged. Sputum cultures reveal that he has pneumonia. He is started on erythromycin, a macrolide.

What is the mechanism of action of erythromycin?
By binding to 23S rRNA of the 50S ribosomal subunit and blocking translocation

REASONING:

Aminoglycosides = Irreversibly bind to the 30s subunit (16S rRNA) by preventing the formation of the ribosome mRNA complex causing misreading of mRNA
16 of 17
A 40-year-old woman is admitted to the emergency department following an overdose of an unknown substance.

Serial blood tests reveal that the elimination of the drug from the body is directly proportional to the reducing serum concentration of the drug.
First-order kinetics
17 of 17

Other cards in this set

Card 2

Front

Simit fainted after donating blood to the transfusion service.
What describe the changes in the volume of his extracellular fluid (ECF) and intracellular fluid (ICF)?

Back

**Decrease in ECF volume, Unchanged ICF volume**

Reasoning: As Samit was donating blood, blood was lost directly form the ECF volume, decreasing the ECF volume.

Card 3

Front

Minimum effective dose = 580mg
Median effective dose = 800mg
Minimum toxic dose = 1820mg
Median toxic dose = 2200mg
Median lethal dose = 3030mg

A 14 year old boy is being started on drug X. This drug has a very narrow therapeutic index window. The prope

Back

Preview of the front of card 3

Card 4

Front

Neutrophils are an integral part of the innate immune system. chemotaxis allows movement of neutrophils .
What biological process found in the neutrophil allows for the actual movement of the neutrophil?

Back

Preview of the front of card 4

Card 5

Front

What value below is used to compare the efficiency of dug?

Back

Preview of the front of card 5
View more cards

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