Tuberculosis

1. A TB skin test which involves injecting purified protein derivative tuberculin into the skin. A small red bump indicates latent TB. A strong reaction could be active TB. BCG vaccinated pts may also have reaction. Risk of false positives (7, 4)
6. The vaccine given to at-risk patients to protect them from TB (3)
7. Persistent cough, bloody phlegm, weight loss, night sweats, high temperature, fatigue, loss of appetite and swellings in the neck are all what? (8)
8. The internalisation of mTB by macrophages, the induction of proinflammatory cytokines, recruitment of immune cells contain myobacterium in granulomas. This containment becomes what? (6, 2)

2. The treatment given to those with multi-drug resistent TB where second-line treatment is limited (12)
3. The name given to drug-resistant TB where even second-line drugs have become resistant (3, 2)
4. Having a weakened immune system, being in close contact with someone with TB, people who have immigrated from areas with high risk of TB are all what? (4, 7)
5. 3 months isoniazid (with pyridoxine) and rifampacin OR 6 months isoniazid (with pyridoxine) are given to which pts? (6, 2)
9. The phase of treatment for active TB without CNS involvement where isoniazid (with pyridoxine) and rifampacin are given for 4 months (12)
10. The phase of treatment for active TB without CNS involvement are the drugs isoniazid (with pyridoxine), rifampicin, pyrazinamide and ethambutol given for 2 months (7)

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