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6. What happens during initiation?

  • complex forms, initiator tRNA charged with methionine + small ribosomal subunit bound to mRNA triggers beginning of translation
  • more than 1 ribosome moves along mRNA at one time
  • ribosome moves along mRNA in 5'-to-3' direction, polypeptides grow from N terminus, charged tRNA's bring amino acids to the ribosome sequentially
  • presence of stop codon in A site of ribosome, completed protein released

7. What happens during termination?

  • more than 1 ribosome moves along mRNA at one time
  • complex forms, initiator tRNA charged with methionine + small ribosomal subunit bound to mRNA triggers beginning of translation
  • presence of stop codon in A site of ribosome, completed protein released
  • ribosome moves along mRNA in 5'-to-3' direction, polypeptides grow from N terminus, charged tRNA's bring amino acids to the ribosome sequentially, specificity provided by: the anticodon interaction and the accuracy of aminoacyl-tRNA synthetases.