Stem cells

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  • Created by: Alex
  • Created on: 27-05-13 19:15
In cells division, what is cleavage?
Mitotic cell divisions, without growth, that converts the zygote into a multicellular blastula
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whats a totipoten cell
has a complete set of genetic instructions required to direct normal development of an organism
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8 stages of early embryo development
1. Zygote (egg+sperm) 2.totipotent fertilised egg 3.2 cell stage 4.4 cell stage 5.early 8 cel 6.compacted 8 cell 7. morula 8-16-32 cells 8.blastocyst 32-64 cells
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whats a blastula
Hollow ball of cells produced by cleavage of a fertilised ovum
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whats a blastocyst
A mammalian blastula
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what are the 2 distinctive tissues in the blastocyst stage
Inner cell mass and Trophectoderm/trophoblast
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whats the function of the inner cell mass
Give rise to embryonic tissues & yolk sac - one side of ring of trophoblast cells
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What does the placenta develop from?
the trophectoderm
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Whats the chorion
extraembryonic membrane that forms an outer cover around the embryo and in mammals contributes to formation of the placenta
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pluirpotent cell
can give rise to all embryonic tissue - not all type of cells
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clonogenic
give rise to a cone of cells
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what is dipause?
Suspended growth/development
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why does dipause happen?
arrest embyonic development - so young born at the optial time
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what regulates diapause?
LIF (Leukemia inhibitory factor) - mediates cellular pathways that maintian self-renewal
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Totipotent stem cel
Sufficient to form entire organism - zygot
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Pluripotent
Able to form all body's lineages including germ cell and some extraembryonic cells
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multipotent
can form multiple lineages that constitue an entire tissue or tissues
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unipotent
cells with capacity to give rise to a single cell type
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which are the main transcription factors in regulating pluripotency
Oct-4 and Nanog
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types of stem cells
embryonic, fetal, adult and reprogrammed cells
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whats a totipoten cell

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has a complete set of genetic instructions required to direct normal development of an organism

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8 stages of early embryo development

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Card 4

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whats a blastula

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Card 5

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whats a blastocyst

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