Snake Venoms

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1. what does a dendro neurotoxin do?

  • blocking cholinergic receptors
  • block neurotransmitter transmission on pre-synaptic membrane by binding to Nav channels to shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous/repetitive firing
  • block subtypes of potassium voltage gated channels, enhancing acetylcholine release resulting in hyperexcitibity
  • inhibit nicotinic acetylcholine receptor on post-synaptic membrane
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2. which statement is true about cardiotoxins?

  • affect the cytosol of cardiac fiber cells
  • produce irreversible depolarisation in cardiac fibre cells
  • mostly in vipers
  • cause hypertension

3. what is true about c-type lectins?

  • inhibit platelets
  • attack endothelial and smooth muscle cells
  • activate platelets
  • neurotoxin

4. what is true about L-amino oxidase?

  • produces alpha keto acids
  • prolific effects
  • oxidation produces hydrogen peroxide and ammonia which causes hemorrhagic and necrotic effects

5. which is not a pro-coagulent enzyme classes under serine proteases?

  • factor V activators
  • plasminogen activators that convert plasminogen to plasmin through fibrinolysis
  • platelet aggregators such as factor XIII to crosslink fibrin clot
  • kininogenases that cleave kiniogen to release kinins to alter blood pressure
  • thrombin-like enzymes that cleave fibrinogen
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