Snake Venoms

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what is characteristic of an endometalloprotease?
affect collagen in blood vessels around bite site causing hemorrhage
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what do endometalloproteases cleave?
polypeptide chains in the middle
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what do anticoagulent metalloproteases cleave?
integrins and fibrin clots
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which is not a pro-coagulent enzyme classes under serine proteases?
plasminogen activators that convert plasminogen to plasmin through fibrinolysis
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What is true about Hyaluronidase?
cleaves hyaluronic acid present in the ECM
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what is true about L-amino oxidase?
produces alpha keto acids
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what does an alpha neurotoxin do?
inhibit nicotinic acetylcholine receptor on post-synaptic membrane
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what does a beta neurotoxin do?
block neurotransmitter transmission on pre-synaptic membrane by binding to Nav channels to shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous/repetitive firing
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what does a kappa neurotoxin do?
blocking cholinergic receptors
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what does a dendro neurotoxin do?
block subtypes of potassium voltage gated channels, enhancing acetylcholine release resulting in hyperexcitibity
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which statement is true about cardiotoxins?
produce irreversible depolarisation in cardiac fibre cells
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what is true about myotoxins?
creatine kinase and myoglobulin production can lead to rhabdomyolysis
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which statement is true about three-finger toxins?
main venom componants of Elapidae family
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what is false about cysteine-rich secretory proteins?
three beta stranded loops emerging from a globular core and stabilised by four conserved disulfide bridges
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what is true about c-type lectins?
attack endothelial and smooth muscle cells
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what is false about disintegrins?
elapid venom
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Other cards in this set

Card 2

Front

what do endometalloproteases cleave?

Back

polypeptide chains in the middle

Card 3

Front

what do anticoagulent metalloproteases cleave?

Back

Preview of the front of card 3

Card 4

Front

which is not a pro-coagulent enzyme classes under serine proteases?

Back

Preview of the front of card 4

Card 5

Front

What is true about Hyaluronidase?

Back

Preview of the front of card 5
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