Molecular Basis of Drug Action

IC50
The concentration of the drug that is required for 50% inhibition of the measured system. The smaller the value (or the higher the pIC50), the more potent the drug.
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EC50
The concentration of the drug that is required for 50% maximal effect in the measured system
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Kd
A dissociation constant - the binding affinity of the drug (the lower the value, the higher the binding affinity)
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Ki
A dissociation constant - the binding affinity of the enzyme inhibitor
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AUC
Area under curve - a measure of the total drug exposure
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Cmax
Maximum concentration
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T 1/2 / Cl
Half-life/clearance - measures the extraction rate of the compound
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Bioavailability
The % dose that reaches the systemic circulation
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Fabs
Fraction absorbed: the fraction of the dose that permeates the gut (0=poor, 1=perfect)
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Vdss
Volume of distribution: a theoretical measure of the extent of distribution from plasma into tissues
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Solubility
logS = 0.5 - 0.01 (MP-25) - logP
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First pass effect
The metabolism directly following absorption from the gut
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Other cards in this set

Card 2

Front

The concentration of the drug that is required for 50% maximal effect in the measured system

Back

EC50

Card 3

Front

A dissociation constant - the binding affinity of the drug (the lower the value, the higher the binding affinity)

Back

Preview of the back of card 3

Card 4

Front

A dissociation constant - the binding affinity of the enzyme inhibitor

Back

Preview of the back of card 4

Card 5

Front

Area under curve - a measure of the total drug exposure

Back

Preview of the back of card 5
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