Respiratory drugs 0.0 / 5 ? PharmacyRespiratory SystemUniversityNone Created by: SamDaviesCreated on: 02-05-19 00:49 67391052814 Across 1. An anti-IgE monoclonal antibody used in severe persistent allergic-type asthma. It is used as an add on therapy (10) 4. An example of a leukotriene receptor antagonist (leukotrienes are part of the inflammatory cascade so these are antiinflammatories) (12) 9. An oral glucocorticoid treatment which can be given short-term (e.g. 10 days) in severe exacerbations of asthma or COPD (12) Down 2. An example of a muscarinic antagonist other than tiotropium. These block the M1, M2 and M3 receptors in bronchial smooth muscle. They are used in the management of asthma combined COPD (11) 3. An example of a long-acting beta 2 agonist other than formeterol. These should only be given to pts already taking an inhaled corticosteroid (10) 5. An oral phosphodiesterase 4 inhibitor used to reduce exacerbations in patients where severe chronic bronchitis. Cannot be used for acute relief from bronchospasm but does reduce inflammation in COPD (11) 6. An example of a mast cell stabiliser which prevents the release of antihistamines. The dose is 3-4 times daily. Should not be given in acute exacerbations of asthma (6, 12) 7. An example of a methylxanthine which has a narrow therapeutic index, side effects similar to the CNS hyperactivity of caffeine, and has interactions with erythromycin, smoking, heart failure, pneumonia (12) 8. An example of a short-acting beta 2 agonist other than tertbutaline. These drugs bind to β-adrenoreceptors on the smooth muscle of the bronchi. β2 receptors are also present in myocardial tissue, so side effects include tachycardia and palpitations. (10) 10. This drug class reverses mucosal oedema, decreases the inflammatory cascade and inhibits the release of leukotrienes. They reduce the hyperesponsiveness of airway smooth muscle to bronchoconstrictor stimuli (14)
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