Pharmaceutical Semi-solids

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  • Created by: SamDavies
  • Created on: 15-04-18 16:59
Y U T L W A B S O R P T I O N B A S E J E
O H S P A X R F D G E S A S G C J M Y M N
I E R E T G W O D R N C C V O Q I E M D N
L W E S E M C K H T R H K R D U U S E F A
I A C A R G A D Y A X U V B E D M A T K H
N T N B S S R J L V T T C J E W I B H R S
W E A R O W M T L B T O U K M A H E Y O W
A R H E L D U N E L X P D E N T B L L R R
T I N T U U V L J B S W Y B Y E L B C C L
E N E A B P X Y H E O S Y M P R U I E I L
R O Y W L R O E T N K D W C D I P C L L U
C I T N E X M X N A U S E P L N E S L L J
R L I I O V S Y A I E D P H M O R I U D G
E C S L I G A P C N I H A C V I K M L F K
A R O I N I F M A V L N C D C L M R O D V
M E C O T M A P G U I Q O B W B S E S N H
X A S R M S K M A N K B Q C R A U T E N C
L M I E E E X R R D H J T P X S E A O I L
V E V A N K J E T M J R Y I Q E P W U R I
C W V F T I I H J U R B Y S C P E P E W Y
G G O U A N V U W P Y N S H I J Q T W J G

Clues

  • A mixture of solid and liquid versions of polyethylene glycol. Easily washed off and non-occlusive. Used in burns dressings as lubricants and as vehicles that allow passage of drugs into the skin (5, 7, 8)
  • An example of a non-greasy paste (10, 5)
  • Colloidal silicon dioxide, aluminium monostearate, phosphatidylcholine (9, 9)
  • Example of a semi-synthetic material found within the liquid phase of gels (15)
  • Made of oleaginous base + water + o/w surfactant, is hydrous and hydrophilic, easy to spread, washable, unstable, not occlusive, incorporates solid, liquid, and non-hydrolyzable drugs (3, 2, 5, 4)
  • Made of oleaginous base + water + w/o surfactant, is hydrous and hydrophilic, moderately easy to spread, poorly washable, unstable, sometimes occlusive, incorporates solid, liquid and non-hydrolyzable drugs (5, 2, 3, 4)
  • Made of oleaginous base and w/o surfactant, is anhydrous but hydrophilic, is difficult to spread, non-washable, occlusive, incorporates solid, oily, non-hydrolyzable drugs as well as small amounts of aqueous solutions (10, 4)
  • Made of polyethylene glycols, is anhydrous/hydrous and hydrophilic, easy to spread, stable, not occlusive, incorporates solid drugs and aqueous solutions (5, 8, 4)
  • Produced by emulsifying agents of natural origins, like beeswax, wood alcohols/fat. Provide an oily barrier that reduces water loss from the stratum corneum. Good emollient properties. (5, 2, 3, 5)
  • Produced by synthetic waxes, like macrogol. Best for achieving rapid drug absorption and penetration. Suitable for application to oozing wounds (3, 2, 5, 5)

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