M.o.A = broken down into organic acids (fatty acid metabolites, hydrogen, methane), increases water content in stool/stool softening, increases bowel movement frequency
4 of 6
Lactulose:
Absorption? Distribution?
A = <3% absorbed by small intestine, negligible amounts of metabolites absorbed by large intestine
D = Negligible amounts absorbed into body, majority remains around GI tract
5 of 6
Lactulose:
Metabolism? Elimination?
M = if saccharolytic bacteria present in large intestine, then metabolised into lactic+acetic+formic acid (ie E.Coli)
E = majority via stool. <3% renal within 24 hours.
6 of 6
Other cards in this set
Card 2
Front
Lactulose:
Indications? Cautions?
Back
I = Constipation, hepatic encephalopathy
C = galactosaemia, GI perforation, lactose intolerance
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