Medications - Ibuprofen - Flashcards in University Nursing

Created by: MillieJ_02
Created on: 13-04-22 22:40

Ibuprofen:
Route? Dose Range?

R = Oral, Topical, Intravenous
D.R = 300-400mg, 3/4 x daily

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Ibuprofen:
Indications? Cautions?

I = pain + inflammation, rheumatic disease, dental pain, migraines, mild - moderate pain (dysmenorrhoea)
C = active GI bleeding, varicella infection, heart failure

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Ibuprofen:
Side effects? Toxicity?

S.E = nausea, headaches, GI discomfort, hypersensitivity, skin reactions
T = epigastric pain, tinnitus, vomiting

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Ibuprofen:
Mechanism of Action?

M.o.A = inhibits prostaglandin (pain/fever) + thromboxane (blood clotting stimulators) synthesis via arachidonic acid pathway

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Ibuprofen:
Absorption? Distribution?

A = rapidly in upper GI tract (oral), peak conc. 1-2 hours post extravascular administration. Rate decreases with food consumption
D = vol. 0.1L/kg. 99% plasma protein bound (saturable + non linear), conc. greater 20mcg/ml

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Ibuprofen:
Metabolism? Elimination?

M = via liver through hydroxylation + carboxylation, metabolites in cp450 system produces 1-hydroxyibuprofen. Conjugation -> glucuronide (oxidative metabolites)
E = 90% via urine. biliary excretion - 1% unchanged. 99% after 24 hours

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Card 2

Front

Ibuprofen:
Indications? Cautions?

Back

I = pain + inflammation, rheumatic disease, dental pain, migraines, mild - moderate pain (dysmenorrhoea)
C = active GI bleeding, varicella infection, heart failure

Card 3

Front

Ibuprofen:
Side effects? Toxicity?

Back

Card 4

Front

Ibuprofen:
Mechanism of Action?

Back

Card 5

Front

Ibuprofen:
Absorption? Distribution?

Back

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Medications - Ibuprofen