4 polypeptdie chians.-heavy or light in nature. constant and variable region. varible responible for antigen binding. c regions bind to efffector cells
2 of 12
name 5 antibodie classes
D M(pentamer) G E I (dimer)
3 of 12
hoew many CH domains do each class have
A, D, G all 3 CH. M E both 4 CH domains
4 of 12
what are the hypervaribale regions
on v regions. complementary determinign regions (cdr). created at a DNA level using V D or J gene segments in rearranged sequences. x3 Vh x3Vl - 6 hypervriable loops
what arfe monclonal antibodies, describe two types of action
from mice, use to deplete immune system. depleting= bind to target and make the molcule a target for macrophages or nks. non deplteing- target fnction protiens-dont kill cell.
10 of 12
probles with monclonal?
immune response to non human antibodes
11 of 12
solutions?which is best
1. chimeric- mouse V and human C. 2. humanised- mouse hyperV human the rest. 3.fully humanised- entirely human, come form cell lines-the best
12 of 12
Other cards in this set
Card 2
Front
describe antibody structure
Back
4 polypeptdie chians.-heavy or light in nature. constant and variable region. varible responible for antigen binding. c regions bind to efffector cells
Comments
No comments have yet been made