6. Which of the following drugs is a thrombin inhibitor?
Heparin
Warfarin
Dabigatran
Apixaban
7. What is the name of the protein which binds to thrombin to initiate negative feedback of the coagulation cascade by activating protein C - this degrades factors VIIIa and Va
Plasminogen
Thrombomodulin
tPA and uPA
Prothrombin
8. What is alpha II b beta 3?
Platelet cell surface receptor
Coagulation factor
Intragranular platelet substance
Fibrinolytic
9. Activated platelets signal to other platelets to activate or attract other platelets to the site of activation through which signalling mechanism?
Neurocrine
Autocrine
Paracrine
Endocrine
10. What is the complex formed when activated platelets cause the flipping of phosphatidyl serine to the outer membrane surface so that clotting factors can bind?
Thrombin-clotting factor complex
Prothrombinase complex
Membrane attack complex
11. Which of the following are haemostatic functions of thrombin?
Vasoconstriction
Positive feedback of coagulation cascade
Platelet activation
All of the above
Production of fibrin clots
12. What is haemostasis?
Leaky blood vessels
Bleeding from a ruptured blood vessel
The stopping of bleeding
The formation of a blood clot inside a blood vessel
13. What are the compensatory mechanisms involved during blood loss?
All of the above
Catecholamine and vasopressin release
Baroreceptor + chemoreceptor reflexes
RAAS activation
14. What are the signs and symptoms of hypovolemic shock?
Rapid breathing, confusion, agitation
All of the above
Tachycardia
Reduced systolic pressure
15. Which ligand binds to alpha II b beta III?
Thromboxin A2
Fibrinogen
Thrombin
Fibrin
16. Which of the following are inhibitors of platelet activation?
Thrombin
Fibrinogen
Nitric oxide
Collagen
17. Which drug inhibits vitamin K (epoxide) reductase in the liver which prevents the activation of certain coagulation factors?
Apixaban
Warfarin
Dabigatran
Heparin
18. Give an example of intragranular substances which are released during platelet activation
Nitric oxide
CD39
Thromboxin A2, ADP
PGI2
19. What are examples of volume expanders which can be given during mild haemorrhage?
All of the above
Crystalloids
Salt solutions
Colloids
20. Which of the following is a plasmin inhibitor?
