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6. Common terms for drug receptor interactions are
- Blocker
- Agonists
- Affinity
- Antagonists
- Efficacy
7. Potency= agonist x efficacy
8. Which is false of agonisim
- Dose response curves are sigmoidal shaped
- The maximum biological response is the same as the tissue reponse
- Maximal response to a drug is the Emax
- In measuring drug action you measure physiological response
- Agonists can be divided into two categories full and partial
9. A full agonist is when maximum drug response is the same as maximum tissue response
10. Which is false of partial agonists
- A partial agonist gives less of a physiological response on the dose response curve
- An analogy for a partial agonist is a badly cut key
- Binds to a receptor but does not always produce a cellular response
- Has similar efficacy as a full agonist
- Acts as an antagonist as well as an agonist
11. Antagonists bind to a receptor to prevent agonist binding
12. Which is false of competitive antagonism
- The binding of a drug is generally strong but easily broken
- The antagonist competes with the bodies natural agonist for binding
- In the presence of a full agonist the maximal tissue repines is not decreased it just needs a larger dose of agonist
- Agonist occupancy is reduced in the presence of a competitive antagonist
- Increasing the concentration of an agonist will eventually overcome the action of the competitive antagonist
13. Which is false of irreversible antagonism
- Most antagonists used clinically do not use irreversible antagonism
- The addition of large amounts of agonist will result in a reduction in the irreversible antagonists action
- It dissociates from it
- The bind between the irreversible antagonist and the target protein is strong
14. Which is false of enzymes
- Enzymes are critical for maintaining homeostasis
- Drugs which target enzymes promote the action of the enzyme
- A protein that speeds up a biological reaction
- Enzymes are highly specific for the type of reaction they catalyse
15. Competitive inhibition which is false
- The chemical bonds are weak and easily broken
- This is essentially the same process as irreversible antagonism
- The drug competes with natural substrate for the binding site on the enzyme
- Drugs interact with the activity site in a similar way to the natural substance
16. Which is false of irreversible inhibition
- For the body to overcome this it will need to make more enzymes
- The action although very strong is short lived
- Most drugs in clinical use do not use irreversible inhibition
- The enzyme is irreversibly inhibited
- The drug binds to the enzyme using a strong bond
17. Carrier proteins which is false
- The Carrier proteins can be targeted
- The action of drugs on these carrier proteins can be reversible or irreversible
- The carrier proteins are non specific
- Ions and neurotransmitters are too polar to cross cell membranes so use carrier proteins
18. Which is false of ion channels
- Local aneasethic is an example
- Drugs are unable to modulate the activity of the ion channel
- These can be targeted by drugs and blocked
- Ion channels act as gated tunnels to allow the passage of ions across membranes
19. Which is not a form of drug antagonism
- Therapeutic antagonism
- Pharmokokinetic antagonism
- Chemical antagonism
- Physiological antagonism
20. Which is false of non competitive antagonism
- Refers to the situation where an antagonist interferes with the cellular response of the agonist
- Agonist binding occurs as normal
- The non competitive antagonist acts to induce part of the cellular response of the agonist
- Calcium channel blockers are an example