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6. Common terms for drug receptor interactions are

  • Blocker
  • Agonists
  • Affinity
  • Antagonists
  • Efficacy

7. Potency= agonist x efficacy

  • False
  • True

8. Which is false of agonisim

  • Dose response curves are sigmoidal shaped
  • The maximum biological response is the same as the tissue reponse
  • Maximal response to a drug is the Emax
  • In measuring drug action you measure physiological response
  • Agonists can be divided into two categories full and partial

9. A full agonist is when maximum drug response is the same as maximum tissue response

  • True
  • False

10. Which is false of partial agonists

  • A partial agonist gives less of a physiological response on the dose response curve
  • An analogy for a partial agonist is a badly cut key
  • Binds to a receptor but does not always produce a cellular response
  • Has similar efficacy as a full agonist
  • Acts as an antagonist as well as an agonist

11. Antagonists bind to a receptor to prevent agonist binding

  • True
  • False

12. Which is false of competitive antagonism

  • The binding of a drug is generally strong but easily broken
  • The antagonist competes with the bodies natural agonist for binding
  • In the presence of a full agonist the maximal tissue repines is not decreased it just needs a larger dose of agonist
  • Agonist occupancy is reduced in the presence of a competitive antagonist
  • Increasing the concentration of an agonist will eventually overcome the action of the competitive antagonist

13. Which is false of irreversible antagonism

  • Most antagonists used clinically do not use irreversible antagonism
  • The addition of large amounts of agonist will result in a reduction in the irreversible antagonists action
  • It dissociates from it
  • The bind between the irreversible antagonist and the target protein is strong

14. Which is false of enzymes

  • Enzymes are critical for maintaining homeostasis
  • Drugs which target enzymes promote the action of the enzyme
  • A protein that speeds up a biological reaction
  • Enzymes are highly specific for the type of reaction they catalyse

15. Competitive inhibition which is false

  • The chemical bonds are weak and easily broken
  • This is essentially the same process as irreversible antagonism
  • The drug competes with natural substrate for the binding site on the enzyme
  • Drugs interact with the activity site in a similar way to the natural substance

16. Which is false of irreversible inhibition

  • For the body to overcome this it will need to make more enzymes
  • The action although very strong is short lived
  • Most drugs in clinical use do not use irreversible inhibition
  • The enzyme is irreversibly inhibited
  • The drug binds to the enzyme using a strong bond

17. Carrier proteins which is false

  • The Carrier proteins can be targeted
  • The action of drugs on these carrier proteins can be reversible or irreversible
  • The carrier proteins are non specific
  • Ions and neurotransmitters are too polar to cross cell membranes so use carrier proteins

18. Which is false of ion channels

  • Local aneasethic is an example
  • Drugs are unable to modulate the activity of the ion channel
  • These can be targeted by drugs and blocked
  • Ion channels act as gated tunnels to allow the passage of ions across membranes

19. Which is not a form of drug antagonism

  • Therapeutic antagonism
  • Pharmokokinetic antagonism
  • Chemical antagonism
  • Physiological antagonism

20. Which is false of non competitive antagonism

  • Refers to the situation where an antagonist interferes with the cellular response of the agonist
  • Agonist binding occurs as normal
  • The non competitive antagonist acts to induce part of the cellular response of the agonist
  • Calcium channel blockers are an example