Factors affecting drug metabolism

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S K H O U T R O L E A N D O M Y C I N P P
L R C J H O F Y Y I S A P G R O H G U X T
E T H O M O D I M E R S V N W V R E J C J
P M U P N J Q K R R P N Y A Y C B N G P Q
R Q P U I A V O Q J I Y G G B E O I P G T
W I K N J W J M H U N N V Q P M Y D T S A
Q Q I Y G S A K Y J X H O F D C L I S G O
O G N A V Q W B L F G H Y H C P X N E B M
V K E R N I C T E R U S D W C L C I C V S
O S U L F A P H E N A Z O L E A G U H C G
F U R A F Y L L I N E P E X G U B Q V Y C
U K E W G L U C U R O N I D A T I O N W K
C F J T J E Q F P W O R C K G C W J N Y O
R N R E P R E S S I V E J Y P W E M M O J
M P H E N O B A R B I T O N E E S W S X F
H K B Q O D X I S U C F V Y S J C A V F F
X H B C B X E W V U Y M B M K G F A U Q T
L A K R I F A M P I C I N G S A B H I K M
C C Y E K M N T K C J V K L T K L N K X U
N B D Y L Q Y I I F D L Q N S D V R U H L
J T F O B E T D S J X Q H L M N M E S M V

Clues

  • Chronic alcoholism can also effect other metabolism reactions leading to changes in NAD(P)H/NAD(P) ratio in? (15)
  • CYP1A2 inhibited by? (11)
  • CYP2C9 inhibited by? (14)
  • CYP2D6 inhibited by? (9)
  • CYP3A4 inhibited by? (14)
  • Inflammation has what effect on CYP450 expression? (10)
  • Lack of bilirubin glucuronidation in neonates can lead to? (11)
  • Sterod hormone receptors (GR,MR etc) bind as? (4, 6)
  • What drug when taking with the contraceptive pill can decrease the protection against pregnancy? (10)
  • Which drug is susceptible to tolerance after it induces its own metabolism by continuous exposure? (14)

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