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6. what is SIRT1

  • type of cyclin
  • NAD dependent deactylase
  • IDK
  • histone methyltransferase

7. Phenotype of Lin-29

  • skips L4
  • LOF repeated L4 divisions
  • no l4 division

8. What does miR9 do

  • Repress E-cadherein translation
  • Repress tumour metastasis
  • promote E-cadherein translation

9. How does Lin-28 inhibit Let-7 biogenesis

  • inhibits dicer cleavage of Let-7, recruitment of poly uridylation enzyme
  • recruitment of poly uridylation enzyme
  • Inhibits dicer cleavage of Let-7,

10. Identifcation of mRNA targets is

  • Poor
  • Good

11. Lin-28 is knocked out in L2 by

  • Lin4
  • Lin-14
  • Lin-41

12. What percentage of human genes are tagetted

  • 60%
  • 90%
  • 40%
  • 50%

13. Ontogeny recapitulates phylogeny means:

  • During development of an organism, you recapitulate all of evolution
  • you recapitulate all of evolution
  • During development of an organism

14. Relationship between Lin-28 and Let-7

  • Lin 28 negatively regualtes Let-7 activity in L1
  • Lin 28 negatively regualtes Let-7 activity in L2
  • Lin 28 negatively regualtes Let-7 activity in L3
  • Lin 28 negatively regualtes Let-7 activity in L4

15. Let-7 promotes differentiation so is therefore a

  • Tumour supressor
  • Oncogene

16. Lin-28 is a what

  • Protein
  • RNA

17. Lin-28 promotes stemness and is therefore a

  • Oncogene
  • Tumour supressor

18. miRNA that targets Rb

  • miR106
  • miR145
  • miR101
  • miR34a

19. Does Let7 inhbit Lin-41

  • yes
  • no

20. mi145 has what feature and targets what

  • P53 response element in its coding region, C-myc
  • P53 response element in its promoter region, targets c-Myc
  • P21 response element in its promoter region, Rb