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6. what is SIRT1
- type of cyclin
- NAD dependent deactylase
- IDK
- histone methyltransferase
7. Phenotype of Lin-29
- skips L4
- LOF repeated L4 divisions
- no l4 division
8. What does miR9 do
- Repress E-cadherein translation
- Repress tumour metastasis
- promote E-cadherein translation
9. How does Lin-28 inhibit Let-7 biogenesis
- inhibits dicer cleavage of Let-7, recruitment of poly uridylation enzyme
- recruitment of poly uridylation enzyme
- Inhibits dicer cleavage of Let-7,
10. Identifcation of mRNA targets is
11. Lin-28 is knocked out in L2 by
12. What percentage of human genes are tagetted
13. Ontogeny recapitulates phylogeny means:
- During development of an organism, you recapitulate all of evolution
- you recapitulate all of evolution
- During development of an organism
14. Relationship between Lin-28 and Let-7
- Lin 28 negatively regualtes Let-7 activity in L1
- Lin 28 negatively regualtes Let-7 activity in L2
- Lin 28 negatively regualtes Let-7 activity in L3
- Lin 28 negatively regualtes Let-7 activity in L4
15. Let-7 promotes differentiation so is therefore a
- Tumour supressor
- Oncogene
17. Lin-28 promotes stemness and is therefore a
- Oncogene
- Tumour supressor
18. miRNA that targets Rb
- miR106
- miR145
- miR101
- miR34a
19. Does Let7 inhbit Lin-41
20. mi145 has what feature and targets what
- P53 response element in its coding region, C-myc
- P53 response element in its promoter region, targets c-Myc
- P21 response element in its promoter region, Rb