Drugs 0.0 / 5 ? MedicinePharmacologyUniversityNone Created by: danhernCreated on: 28-12-17 16:48 42973101658 Across 1. Interferes with bacterial protein synthesis: prevents translocation of elongation factor G from the ribosome. Can also inhibit chloramphenicol acetyltransferase enzymes. (7, 4) 4. Smooth muscle relaxer / bronchodilation. Also inhibits release of bronchoconstriction agents. Relaxes smooth muscle by increasing cAMP production, lowering calcium concentrations leading to muscle relaxation. (10) 5. Inhibits arabinosyl transferases which is used in cell wall biosynthesis. bacterial cell wall complex is inhibited leading to increase in cell wall permeability. (10) 8. Penetrates bacterial cell wall and binds to 50S subunit of bacterial ribsome (14) 9. Glucocorticoid. Supresses humoral immune responses, to inhibit leukocyte infiltration. (12) Down 2. Inhibits bacterial topoisomerases, DNA replication and transcription is inhibited. (12) 3. Clearing laxative. 2 active ingredient; Sodium Picosulfate and Magnesium Citrate. S.picosulfate is mechanical laxative, activated in large intestine by bacteria, stimulates nerves causing contraction to move along bowel contents. M.Citrate is osmotic (7) 6. Same as above with: Starch included to help stools become more solid more quick. (9) 7. Irreversibly binds to 30S subunit and RNA wobble base of tRNA leading to incorrect amino acids and non functional or toxic peptides produced. (12) 10. Prodrug, activated by bacterial catalase. Inhibits synthesis of mycoloic acids which are essential component of bacterial cell wall (9)
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