6. Which anti-diabetic agent is most likely to cause weight loss?
DPP-4 inhibitors
Pioglitazone
Metformin
Sulphonylureas
7. Which drug is not an example of a Sulphonylurea?
All of them are
Tolbutamide
Gliclazide
Glipizide
8. Which is not a side effect of thiazolidinediones?
Bone fracture risk
Weight loss
Infection risk
Peripheral oedema
9. How do biguanides (metformin) work?
Activates PPary which binds to DNA and increases insulin sensitivity and uptake of fatty acids in adipose tissue and glucose uptake. Lowers hepatic glucose production.
Activate AMP kinase and decreases hepatic glucose production, intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake
Inactivates ATP sensitive K+ channel which increases Ca2+ influx and thus insulin secretion. Also increases glucose sensitivity in beta cells and lowers hepatic glucose production.
Inhibits SGLT2 thus preventing reabsorption of glucose in proximal tubule of kidneys.
10. Which of these drugs interact with SGLT2 inhibitors?
Iv contrast media, trimethoprim, ACEI
Duiretics, digoxin, carbamazepine
CCB, salbutamol, diuretics
salbutamol, ACEI, beta blocker
11. Which of the following is not a common side effect of insulin therapy?
Bradycardia
Weightt gain
Hypoglycaemia
Redness, swelling and itching at injection site
12. which anti-diabetic agents require monitoring of ketone levels?
Thiazolidinediones
DPP-4 inhibitors
SGLT2 inhibitors
Sulphonylureas
13. Which anti-diabetic drug has been associtated with a small risk of bladder cancer?
