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6. Which anti-diabetic drug has been associtated with a small risk of bladder cancer?

  • SGLT2 inhibitors
  • Pioglitazone
  • Metformin
  • Sulphonylureas

7. Which is not a side effect of thiazolidinediones?

  • Weight loss
  • Bone fracture risk
  • Peripheral oedema
  • Infection risk

8. which anti-diabetic agent is used in pregnancy?

  • Pioglitazone
  • DPP-4 Inhibitors
  • insulin
  • Sulphonylureas

9. Which drug is not an example of a Sulphonylurea?

  • Gliclazide
  • Glipizide
  • All of them are
  • Tolbutamide

10. Which anti-diabetic agent is most likely to cause weight loss?

  • Metformin
  • Pioglitazone
  • Sulphonylureas
  • DPP-4 inhibitors

11. What is the MOA of sulphonylureas?

  • Inactivates ATP sensitive K+ channel which increases Ca2+ influx and thus insulin secretion. Also increases glucose sensitivity in beta cells and lowers hepatic glucose production.
  • Inhibits SGLT2 thus preventing reabsorption of glucose in proximal tubule of kidneys.
  • Activate AMP kinase and decreases hepatic glucose production, intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake
  • Activates PPary which binds to DNA and increases insulin sensitivity and uptake of fatty acids in adipose tissue and glucose uptake. Lowers hepatic glucose production.

12. What is the first line treatment in T2DM with HF or CVD?

  • sulphonylureas
  • pioglitazone
  • SGLT2 inhibitors
  • Metformin

13. What is the first recommended basal insulin therapy of a basal-bolus insulin regimen?

  • Detemir
  • Degludec
  • Lispro
  • NPH