6. Which anti-diabetic drug has been associtated with a small risk of bladder cancer?
SGLT2 inhibitors
Pioglitazone
Metformin
Sulphonylureas
7. Which is not a side effect of thiazolidinediones?
Weight loss
Bone fracture risk
Peripheral oedema
Infection risk
8. which anti-diabetic agent is used in pregnancy?
Pioglitazone
DPP-4 Inhibitors
insulin
Sulphonylureas
9. Which drug is not an example of a Sulphonylurea?
Gliclazide
Glipizide
All of them are
Tolbutamide
10. Which anti-diabetic agent is most likely to cause weight loss?
Metformin
Pioglitazone
Sulphonylureas
DPP-4 inhibitors
11. What is the MOA of sulphonylureas?
Inactivates ATP sensitive K+ channel which increases Ca2+ influx and thus insulin secretion. Also increases glucose sensitivity in beta cells and lowers hepatic glucose production.
Inhibits SGLT2 thus preventing reabsorption of glucose in proximal tubule of kidneys.
Activate AMP kinase and decreases hepatic glucose production, intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake
Activates PPary which binds to DNA and increases insulin sensitivity and uptake of fatty acids in adipose tissue and glucose uptake. Lowers hepatic glucose production.
12. What is the first line treatment in T2DM with HF or CVD?
sulphonylureas
pioglitazone
SGLT2 inhibitors
Metformin
13. What is the first recommended basal insulin therapy of a basal-bolus insulin regimen?